Destination
Panama
Overview
About Panama
Discover amazing cruise itineraries visiting Panama.
Itineraries
Voyages to Panama
Scenic · Scenic Eclipse
Ultimate America's Historic Journey to Panama
22 Days · Oct 2026
From$22,990
Scenic · Scenic Eclipse
Pristine islands of the Bahamas & the Panama Canal
11 Days · Oct 2026
From$11,495
Ponant · L'Austral
From Panama’s wild beauty to Peruvian shores
11 Days · Oct 2026
From$6,600
Hapag-Lloyd Cruises · HANSEATIC inspiration
New York, the Caribbean and Panama: from the Big Apple to the Garden of Eden
15 Days · Oct 2026
Scenic · Scenic Eclipse
Wellness Retreat - Panama City to Valparaiso
10 Days · Oct 2026
From$7,845
Ponant · Le Bellot
Panama, Colombia & Caribbean Islands
13 Days · Oct 2026 · +3 more
From$7,970
Lindblad Expeditions · National Geographic Quest
Panama and Colombia: Exploring the Caribbean Coast
8 Days · Oct 2026 · +1 more
From$4,505
Ponant · Le Bellot
Central America Jewels & Panama Canal
8 Days · Nov 2026 · +6 more
From$5,700
Hapag-Lloyd Cruises · HANSEATIC inspiration
Expedition South America with Panama Canal: a picture book of creation
18 Days · Nov 2026
From$26,770
Ponant · Le Lapérouse
Secrets of Central America
11 Days · Nov 2026 · +15 more
From$8,140
Lindblad Expeditions · National Geographic Quest
Costa Rica and the Panama Canal
8 Days · Nov 2026 · +23 more
From$6,228
Lindblad Expeditions · National Geographic Quest
The Panama Canal, Pearl Islands and Darién Jungle
8 Days · Dec 2026 · +5 more
From$5,228
Silversea · Silver Dawn
Miami, FL to Los Angeles, California
18 Days · Dec 2026
From$10,990
Silversea · Silver Dawn
Miami, FL to Papeete (Tahiti)
40 Days · Dec 2026
From$21,900
Seabourn · Seabourn Quest
126-Day World Cruise: Australia & South Pacific Panorama
126 Days · Jan 2027
From$90,099
Seabourn · Seabourn Quest
12-Day World Cruise: Panama Canal To Callao
12 Days · Jan 2027
From$4,929
Seabourn · Seabourn Quest
62-Day World Cruise: Panama Canal, Polynesia & New Zealand
62 Days · Jan 2027
From$31,024
Seabourn · Seabourn Quest
35-Day World Cruise: Panama Canal Crossing & Polynesia
35 Days · Jan 2027
From$15,809
Seabourn · Seabourn Quest
145-Day World Cruise: Australia & South Pacific Panorama
145 Days · Jan 2027
From$102,099
Lindblad Expeditions · National Geographic Quest
Inland Costa Rica, the Panama Canal and Pearl Islands
9 Days · Jan 2027 · +3 more
From$6,125
Hapag-Lloyd Cruises · MS EUROPA
The diverse west coast of the American continent
29 Days · Feb 2027
From$12,890
Ponant · Le Lapérouse
Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys
8 Days · Feb 2027 · +1 more
From$7,100
Silversea · Silver Nova
Valparaiso to Miami, FL
18 Days · Mar 2027
From$12,670
Seabourn · Seabourn Quest
83-Day World Cruise: Australia In-depth & Panama Canal
83 Days · Mar 2027
From$46,834
Ponant · Le Bellot
Panama, Colombia & Caribbean Islands
11 Days · Mar 2027 · +1 more
From$7,900
Scenic · Scenic Eclipse II
Ultimate South America to the Caribbean through the Panama Canal
25 Days · Mar 2027
From$22,760
Hapag-Lloyd Cruises · HANSEATIC inspiration
Expedition South and Central America with Panama Canal: jungle adventures, Caribbean magic and equatorial discoveries
19 Days · Mar 2027 · +1 more
From$8,990
Lindblad Expeditions · Greg Mortimer
Panama and Costa Rica’s Pacific Coast: A Central America Odyssey
13 Days · Mar 2027 · +1 more
From$9,900
Scenic · Scenic Eclipse II
Pristine islands of the Caribbean & the Panama Canal
12 Days · Apr 2027
From$11,495
Hapag-Lloyd Cruises · MS EUROPA
The fascination of Central America
24 Days · Apr 2027
From$9,590
Explora Journeys · EXPLORA III
A Grand Journey through Balmy Shores & Enchanting Nature to Panama’s Wonders
17 Days · Apr 2027
From$11,735
Polar Latitudes · Discoverer
South American Explorer: Temples, Jungles & the Panama Canal
10 Days · Apr 2027
From$5,457
Aurora Expeditions · Sylvia Earle
Costa Rica & the Panama Canal
12 Days · Apr 2027
From$10,871.25
Explora Journeys · EXPLORA III
A Journey through Enchanting Nature & the Marvels of the Panama Canal
10 Days · Apr 2027
From$7,860
Explora Journeys · EXPLORA III
An Extended Journey from Majestic Horizons to Mayan Gems
21 Days · Apr 2027
From$14,240
Seabourn · Seabourn Quest
46-Day World Cruise: South Pacific & Panama Canal
46 Days · Apr 2027
From$18,699
Explora Journeys · EXPLORA III
A Journey of Mayan Discovery & Mexican Exploration
11 Days · Apr 2027
From$7,280
Explora Journeys · EXPLORA III
An Extended Journey of Ancient Mysteries & Pacific Coastal Wonders
18 Days · Apr 2027
From$11,840
Seabourn · Seabourn Quest
27-Day World Cruise: Hawaii & Panama Canal
27 Days · May 2027
From$9,315
Seabourn · Seabourn Quest
31-Day Panama Canal & Atlantic Passage
31 Days · May 2027
From$11,474
UnCruise Adventures · Safari Voyager
Costa Rica & Panama Coastal Expedition Cruise
15 Days · Sep 2027 · +3 more
From$16,800
Aurora Expeditions · Douglas Mawson
Panama and Costa Rica: Crossing the Canal
10 Days · Oct 2027
From$5,747.5
Scenic · Scenic Eclipse
Ancient Kingdoms and Natural Treasures: Panama to Chile
14 Days · Oct 2027
From$14,995
Scenic · Scenic Eclipse
The Chairman’s Voyage: Ultimate Ancient Treasures, Fjords & Wonders of South America
26 Days · Oct 2027
From$37,810
Ponant · Le Bellot
Panama, Colombia & Caribbean Islands
10 Days · Nov 2027
From$6,940
Explora Journeys · EXPLORA II
A Journey through Caribbean Havens & the Tropical Gems of Seaside Cities
10 Days · Dec 2027
From$5,730
Hapag-Lloyd Cruises · MS EUROPA 2
A heavenly holiday under palm trees
17 Days · Dec 2027
From$12,890
Seabourn · Seabourn Quest
120-Day Cape To Cape World Cruise: Miami To Southampton
120 Days · Jan 2028
From$77,999
Seabourn · Seabourn Quest
82-Day South America, Antarctica, South Atlantic & Africa
82 Days · Jan 2028
From$45,984
Seabourn · Seabourn Quest
112-Day Cape To Cape World Cruise: Miami To Lisbon
112 Days · Jan 2028
From$72,799
Seabourn · Seabourn Quest
29-Day Panama Canal & Easter Island Explorer
29 Days · Jan 2028
From$15,809
Hapag-Lloyd Cruises · MS EUROPA 2
Pura vida – Costa Rica up close
13 Days · Jan 2028
From$9,490
Seabourn · Seabourn Quest
57-Day Panama Canal, Chilean Fjords, Antarctica & Falklands
57 Days · Jan 2028
From$31,534
Silversea · Silver Ray
Miami, FL to Buenos Aires
33 Days · Jan 2028
From$24,100
Silversea · Silver Shadow
Cartagena to Valparaiso
14 Days · Jan 2028
From$8,300
Silversea · Silver Ray
Miami, FL to Lima (Callao)
12 Days · Jan 2028
From$9,170
Hapag-Lloyd Cruises · MS EUROPA 2
The great diversity of the Caribbean Sea
19 Days · Jan 2028
From$12,740
Seabourn · Seabourn Pursuit
38-Day Panama Canal, Juan Fernandez Islands & Antarctica
38 Days · Oct 2028
From$33,209
Seabourn · Seabourn Pursuit
16-Day Panama Canal & Historic Coasts Of South America
16 Days · Oct 2028
From$9,899
Scenic · Scenic Eclipse
Ultimate Voyage: Caribbean Islands & the Panama Canal
21 Days · Oct 2028
From$20,890
Hapag-Lloyd Cruises · HANSEATIC inspiration
New York, the Caribbean and Panama: When the metropolis and the tropics merge
14 Days · Oct 2028
From$7,890
Scenic · Scenic Eclipse
Voyage of the Tropics: Bahamas, Caribbean & Panama Canal
12 Days · Oct 2028
From$12,095
Scenic · Scenic Eclipse
Ancient Kingdoms & Natural Treasures: Panama to Chile
14 Days · Oct 2028
From$14,395
Hapag-Lloyd Cruises · HANSEATIC inspiration
Expedition South America with Panama Canal: up close with lush nature
19 Days · Oct 2028
From$11,040
Hapag-Lloyd Cruises · MS EUROPA
Island pearls under the Caribbean sun
14 Days · Dec 2028
From$6,140
Hapag-Lloyd Cruises · MS EUROPA
Festive holidays with the scent of tropical nature
17 Days · Dec 2028
From$8,570